Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline.

Background: This document provides evidence-based clinical practice guidelines on the diagnostic utility of nucleic acid-based testing of respiratory samples for viral pathogens other than influenza in adults with suspected community-acquired pneumonia (CAP).Methods: A multidisciplinary panel developed a Population-Intervention-Comparison-Outcome question, conducted a pragmatic systematic review, and applied Grading of Recommendations, Assessment, Development, and Evaluation methodology for clinical recommendations.Results: The panel evaluated the literature to develop recommendations regarding whether routine diagnostics should include nucleic acid-based testing of respiratory samples for viral pathogens other than influenza in suspected CAP. The evidence addressing this topic was generally adjudicated to be of very low quality because of risk of bias and imprecision. Furthermore, there was little direct evidence supporting a role for routine nucleic acid-based testing of respiratory samples in improving critical outcomes such as overall survival or antibiotic use patterns. However, on the basis of direct and indirect evidence, recommendations were made for both outpatient and hospitalized patients with suspected CAP. Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was not addressed in the literature at the time of the evidence review.Conclusions: The panel formulated and provided their rationale for recommendations on nucleic acid-based diagnostics for viral pathogens other than influenza for patients with suspected CAP.

Factors other than medical acuity that influence hospitalisation: a scoping review protocol.

INTRODUCTION: There is evidence that patients are admitted to the hospital with low-acuity medical issues, though delineation of the underlying factors has not been comprehensively explored. This scoping review will provide an overview of the existing literature regarding factors outside of acute medical illness that influence hospitalisation of adults. The review will also seek to provide a review of common language and definitions used in the research on this phenomenon. METHODS AND ANALYSIS: The scoping review framework, outlined by Arksey and O'Malley and expanded on by Levac et al, will be used as the basis for this study. A systematic search of seven databases (PubMed, CINAHL, PsycINFO, EMBASE, Web of Science, Sociological Abstracts and Social Science Abstracts) will be conducted to identify existing literature followed by a standardised two-phase, two-reviewer process to select relevant papers for inclusion. Relevant studies will investigate adult non-psychiatric hospital admission plus at least one additional factor unrelated to medical acuity. Details of the work will be extracted, including the terminology used and perspectives included. An assessment of methodological quality will be performed using a tool designed for mixed-methods systematic review. ETHICS AND DISSEMINATION: The scoping review protocol delineates a transparent and rigorous review process, the results of which will be disseminated through peer-reviewed publication and presentation at relevant local or national meetings. The study does not require ethics approval as the data will be accumulated through the review of published, peer-reviewed literature and grey literature.

Understanding the information needs of public health practitioners: a literature review to inform design of an interactive digital knowledge management system.

UNLABELLED: The need for rapid access to information to support critical decisions in public health cannot be disputed; however, development of such systems requires an understanding of the actual information needs of public health professionals. This paper reports the results of a literature review focused on the information needs of public health professionals. The authors reviewed the public health literature to answer the following questions: (1) What are the information needs of public health professionals? (2) In what ways are those needs being met? (3) What are the barriers to meeting those needs? (4) What is the role of the Internet in meeting information needs? The review was undertaken in order to develop system requirements to inform the design and development of an interactive digital knowledge management system. The goal of the system is to support the collection, management, and retrieval of public health documents, data, learning objects, and tools. METHOD: The search method extended beyond traditional information resources, such as bibliographic databases, tables of contents (TOC), and bibliographies, to include information resources public health practitioners routinely use or have need to use--for example, grey literature, government reports, Internet-based publications, and meeting abstracts. RESULTS: Although few formal studies of information needs and information-seeking behaviors of public health professionals have been reported, the literature consistently indicated a critical need for comprehensive, coordinated, and accessible information to meet the needs of the public health workforce. Major barriers to information access include time, resource reliability, trustworthiness/credibility of information, and "information overload". CONCLUSIONS: Utilizing a novel search method that included the diversity of information resources public health practitioners use, has produced a richer and more useful picture of the information needs of the public health workforce than other literature reviews. There is a critical need for public health digital knowledge management systems designed to reflect the diversity of public health activities, to enable human communications, and to provide multiple access points to critical information resources. Public health librarians and other information specialists can serve a significant role in helping public health professionals meet their information needs through the development of evidence-based decision support systems, human-mediated expert searching and training in the use information retrieval systems.